This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Report of Three Cases

Joseph D. Sherman, MD, PhD; Donald E. Love, MD; J. Frederick Harrington, MD

Arch Intern Med. 1967;120(3):321-326.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

There have been 22 reported cases of Coombs'-positive hemolytic anemia in patients under hypertensive treatment with methyldopa (Aldomet).^1-7,18 In addition, 56 cases have been reported in which the direct Coombs' test was positive without hemolytic anemia.^8-10,18 It would appear that the incidence of Coombs' positivity is dosage dependent.⁹ The purpose of this report is to describe three cases of Coombs'-positive hemolytic anemia in patients treated with methyldopa. The rheumatoid factor and the lupus erythematosus (LE) preparation were also positive in two of these cases. These latter two antibodies are described for the first time in patients given this drug.

Report of Cases

CASE 1.

—A 71-year-old white married woman was admitted to this hospital with complaints of progressive dyspnea and weakness of approximately one month's duration. The patient had essential hypertension diagnosed in 1949 and had been on methyldopa therapy from June 5, 1964, to the day . . . [Full Text PDF of this Article]

Author Affiliations
Framingham and Boston, Mass

From the Department of Hematology and Medicine, Framingham (Mass) Union Hospital, and the Department of Medicine, Boston University Medical Center, Boston.

Footnotes
Received for publication April 4, 1967; accepted May 23.

Reprint requests to Framingham Union Hospital, Department of Hematology, Framingham, Mass 01701 (Dr. Sherman).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?