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Lawrence G. Raisz, MD

Arch Intern Med. 1969;124(4):389-396.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The parathyroids differ from other endocrine glands in several respects. (1) The parathyroids appear late in phylogeny, being seen first in the amphibia. (2) While most endocrine glands make more than one hormone, only one hormone and one secretory cell type are regularly found in the parathyroids. (3) While most endocrine glands are under complex control involving both long and short feedback loops, the parathyroid glands have a unique feedback control by the concentration of divalent cations in the blood. Of course, indirect effects on parathyroid function can occur which act via changes in divalent cation concentration, so that the complexity of parathyroid control may be as great as that of other endocrines.

The physiologic role of the parathyroid glands is to regulate serum ionized calcium concentration. However, changes in the concentration of both magnesium and calcium ions can affect parathyroid function. The chief reason that the parathyroids regulate . . . [Full Text PDF of this Article]

Author Affiliations
Rochester, NY

From the departments of pharmacology and medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY.

Footnotes
Received for publication May 23, 1969; accepted May 27.

Read before the Conference on Divalent

Ion Metabolism and Osteodystrophy in Chronic Renal Failure, Santa Barbara, Calif, Nov 18, 1968.

Reprint requests to Department of Pharmacology, University of Rochester School of Medicine, Rochester, NY 14620.

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