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Some Possible Implications for Diseases of Bone and Other Connective Tissues

Darwin J. Prockop, MD, PhD

Arch Intern Med. 1969;124(5):563-570.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The work performed in this laboratory in the last several years bears only indirectly on the subject of this symposium, but it probably provides a basic framework for biochemical approaches to the problems which occur in bone as a result of long-term dialysis. Collagen is the principal organic constituent of bone, and one of the questions we and others have asked is ¹: How do cells in connective tissue synthesize collagen? Before discussing this question, however, I will present a brief review of the structure of the collagen molecule as it is known.^2-5

Structure of Collagen

The collagen fibers in connective tissues are made up of small fibrils which have a characteristic pattern when examined by electron microscopy (Fig 1). The most characteristic feature of these fibrils is a series of major crossbands which are separated by a distance of approximately 700 Angstroms (A). As was demonstrated primarily . . . [Full Text PDF of this Article]

Author Affiliations

From the departments of medicine and biochemistry, University of Pennsylvania, Philadelphia, and the Philadelphia General Hospital.

Footnotes

Read before the Conference on Divalent Ion Metabolism and Osteodystrophy in Chronic Renal Failure, Santa Barbara, Calif, Nov 19, 1968.

Reprint requests to General Clinical Research Center, Philadelphia General Hospital, 34th St and Curie Ave, Philadelphia 19104 (Dr. Prockop).

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