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Acute Granulocytic Leukemia Complicating Hodgkin's Disease
Martin H. Steinberg, MD;
Colin G. Geary, MB;
William H. Crosby, MD
Arch Intern Med. 1970;125(3):496-498.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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The coexistence of acute leukemia and Hodgkin's disease is rare.1 However, Crosby 2 in a recent survey estimated the incidence of acute granulocytic leukemia in Hodgkin's disease to be increased tenfold, and suggested that this may be a sequel to radiotherapy, not directly related to the disease. We present here two patients with Hodgkin's disease of long duration, in both of whom acute leukemia developed. A refractory sideroblastic anemia, which rapidly progressed to erythroleukemia (acute Di Guglielmo syndrome) developed in one; pancytopenia developed in the other, who died of acute granulocytic leukemia nine months later.
Patient Summaries
In 1954, a 36-year-old woman had Hodgkin's disease involving cervical, supraclavicular, and mediastinal nodes. She received radiotherapy (2,400 roentgens) to these areas. Laboratory values were as follows: hemoglobin, 12.4 gm/ 100 ml; leukocytes, 9,100/cu mm, with 58% neutrophils, 21% lymphocytes, 16% monocytes, and 5% eosinophils. In 1960, adenopathy recurred, with systemic symptoms.
. . . [Full Text PDF of this Article]
Author Affiliations
Boston
From the Blood Research Laboratory, New England Medical Center Hospitals, and the Department of Medicine, Tufts University School of Medicine, Boston.
Footnotes
Received for publication Oct 24, 1969; accepted Nov 4.
Reprint requests to 171 Harrison Ave, Boston 02111 (Dr. Crosby).
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