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Guide to Therapy in Hereditary Hemorrhagic Telangiectasis

Earl W. Campbell, Jr., MD; Douglas Jewson, MD; Enid Gilbert, MD

Arch Intern Med. 1970;125(4):705-707.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome, HHT) is defined as a familial autosomal recessive disease characterized by telangiectasia of skin and mucous membrane vessels tending to manifest bleeding increasingly after the third decade. Lesions have been described as elevated and nodular, simple spiders, violaceous macular, with the most common form being a 1- to 3-mm punctiform nonelevated, purple telangiectasis.^1-3 Documented involvement has included pulmonary, meningeal, cerebral, renal, hepatic, ocular, and aortic lesions in addition to the more frequent dermal and oral manifestations.^3,4

With gastrointestinal bleeding, peptic ulcer may be suspected and both conditions may in fact coexist.⁵ Enteric telangiectasia cannot be demonstrated by studies after barium administration, and direct visualization carries the risk of inducing hem

Received for publication Nov 14, 1969; accepted Dec 30.

From the departments of medicine orrhage. Blind surgical approach frequently may not locate the bleeding site. The complication of repeated hemorrhage and severe . . . [Full Text PDF of this Article]

Author Affiliations
Morgantown, WVa

(Drs. Campbell and Jewson) and pathology (Dr. Gilbert), West Virginia University Medical Center, Morgantown.

Footnotes
Reprint requests to Department of Medicine, West Virginia University Medical Center, Morgantown, WVa 26506 (Dr. Campbell).

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