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Erik De Clercq, MD; Thomas C. Merigan, MD

Arch Intern Med. 1970;126(1):94-108.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Until 1963, only viruses were known to stimulate interferon production in cells. The nucleic acid of the virus was generally regarded as the essential stimulus for interferon production.¹ Rotem et al and Isaacs et al^2,3 demonstrated in 1963 that nonviral nucleic acids, provided they were foreign to the cells (heterologous or chemically modified homologous RNA), could also initiate the production of interferon. Although their "foreign nucleic acid" hypothesis was received with some scepticism and retracted later,⁴ it offered a reasonable explanation for the nucleic acid-induced resistance to viral infection, which had been described⁵ as early as 1953. Moreover, it raised a possible explanation for the antiviral action of agents such as bacteria or apparently nonviral agents as the mold products statolon (culture filtrate of Penicillium stoloniferum) and helenine (mycelium extract of Penicillium funiculosum) which had been found active in a number of experimental viral infections.^6-13 . . . [Full Text PDF of this Article]

Author Affiliations
Stanford, Calif

From the Division of Infectious Diseases, Department of Medicine, Stanford University School of Medicine, Stanford, Calif. Dr. De Clercq is a Lilly International Fellow and "Aangesteld Navorser" of the Belgian Nationaal Fonds voor Wetenschappelijk Ondersoek.

Footnotes
Received for publication Nov 5, 1969; accepted, Jan 28, 1970.

Reprint requests to 300 Pasteur Dr, Stanford, Calif 94305 (Dr. Merigan).

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