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Fred Rosner, MD; Donald C. Aberfeld, MD

Arch Intern Med. 1970;126(6):1010-1013.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1960, Holt and Oram¹ described a syndrome consisting of atrial septic defects, bizarre cardiac arrhythmias, and abnormalities of the upper extremity, particularly the thumb, in numerous members of a family covering at least four generations. One year later, McKusick² mentioned a mother and daughter with this syndrome and suggested the name atriodigital dysplasia. In 1963, Zetterqvist³ reported a third family, mother and son in whom atrial septal defects, bizarre arrhythmias, and the characteristic thumb anomalies were seen. In the same year, Kuhn et al⁴ described a fourth family with this syndrome. Three additional pedigrees were reported by Pruzanski,⁵ Lewis et al,⁶ and Emerit et al⁷ in 1964. The following year, Holmes⁸ described two pedigrees and Emerit et al⁹ reported five additional cases, four of whom had cardiac anomalies other than interatrial septal defects and no cardiac arrhythmias. In 1966, a very extensive pedigree of the Holt-Oram syndrome with detailed . . . [Full Text PDF of this Article]

Author Affiliations
Brooklyn, NY

From the divisions of hematology (Dr. Rosner) and neurology (Dr. Aberfeld), Department of Medicine, Maimonides Medical Center, Brooklyn, NY. Dr. Rosner is now with the Queens Hospital Center, Jamaica, NY.

Footnotes
Received for publication Jan 23, 1970; accepted Sept 10.

Reprint requests to 8268 164th St, Jamaica, NY 11432 (Dr. Rosner).

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