This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (14)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Circulatory State

Edward D. Frohlich, MD; Harriet P. Dustan, MD; Robert C. Tarazi, MD

Arch Intern Med. 1970;126(6):1068-1069.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In a recent communication published in the ARCHIVES Bourne et al¹ reviewed certain published literature concerning intravenous infusions of isoproterenol and related these observations to one of our clinical investigations dealing with patients having "hyperdynamic beta-adrenergic circulatory state".² The authors concluded that (a) our data in 25 normal volunteer subjects and 27 hypertensive patients concerning isoproterenol-induced cardioacceleration failed to coincide with three cited studies involving five, three, and four subjects, respectively^3-5; (b) we failed to answer completely the theoretical questions involved, and (c) our data do not justify therapy of our patients with propranolol hydrochloride.

It is always of great value to question and reevaluate concepts, to confirm or refute observations, and to welcome criticism; however, additional data as an alternative to our published observations were not available. The reader, therefore, is left with a theoretical challenge to real observations. The presentation, therefore, deems our answer mandatory. . . . [Full Text PDF of this Article]

Author Affiliations
Oklahoma City; Cleveland

From the Division of Hypertension, Department of Medicine, the University of Oklahoma Medical Center, Oklahoma City (Dr. Frohlich) and the Research Division, Cleveland Clinic (Drs. Dustan and Tarazi).

Footnotes
Received for publication Sept 1, 1970; accepted Sept 1.

Reprint requests to 800 NE 13th St, Oklahoma City 73104 (Dr. Frohlich).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?