This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (3)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Case Report With Discussion of the Mechanism of Portal Hypertension

Edward K. Denison, MD; Robert L. Peters, MD; Telfer B. Reynolds, MD

Arch Intern Med. 1971;128(2):279-283.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Portal hypertension without cirrhosis of the liver has been described in several hematological conditions.^1-15 Though there may be thrombosis of the portal, splenic, or hepatic veins in cases of the myeloproliferative syndromes,^13-15 many cases have been described in which these veins were patent.^1-8,13 The etiology of portal hypertension in these patients with patent venous systems has not been clearly elucidated. Alternative explanations include increased portal flow secondary to splenomegaly, the "forward flow" theory,^2,3,8 and increased hepatic resistance from infiltrative lesions in portal tracts and sinusoids.^7,13

Portal hypertension without cirrhosis also occurs in tropical splenomegaly¹⁶ and systemic-portal arteriovenous fistulae.^17,18 Investigations in these patients have also suggested that increased portal blood flow may cause portal hypertension in the absence of cirrhosis.^16,17

The case described here represents an example of hematological portal hypertension. Bone marrow obliteration led to hepatosplenomegaly from extramedullary hematopoesis. Portal hypertension became obvious when a large epigastric collateral vein appeared. . . . [Full Text PDF of this Article]

Author Affiliations
Los Angeles

From the departments of medicine and pathology, University of Southern California School of Medicine and John Wesley County Hospital, Los Angeles.

Footnotes
Received for publication July 29, 1970; accepted Sept 10.

Read before the Southern California Society of Gastroenterology, May 26, 1970, Los Angeles.

Reprint requests to 550 Washington St, Suite 123, San Diego, Calif 92103 (Dr. Denison).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?