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Progressive Multifocal Leukoencephalopathy
Lynn W. Lyon, MD;
William F. McCormick, MD;
Sydney S. Schochet, Jr., MD
Arch Intern Med. 1971;128(3):420-426.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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In 1958, Åström et al1 described three cases of a clinically progressive, asymmetric disorder of the central nervous system (CNS) which they named "progressive multifocal leukoencephalopathy" (PML). This disorder was associated with Hodgkin's disease and chronic lymphocytic leukemia in their patients. In reviewing the literature at that time, they found five additional cases which fulfilled their criteria for PML.2-5
Since 1958, many additional cases of PML associated with a variety of underlying disease processes have been described.6-56 The purpose of the present report is to describe a new case of PML occurring in a patient with macroglobulinemia, an association not previously reported. Clinical, pathological, and virologic findings are described.
Patient Summary
A 61-year-old white man was first seen in a local hospital in December 1958 complaining of shortness of breath and abdominal distension. Physical examination revealed a right upper quadrant abdominal mass and a right pleural
. . . [Full Text PDF of this Article]
Author Affiliations
Iowa City
From the departments of neurology and pathology (Neuropathology), University of Iowa ology lege of Medicine, Iowa City.
Footnotes
Received for publication June 10, 1970; accepted Sept 10.
Reprint requests to Room 28, Medical Laboratories, Iowa City 52240 (Dr. McCormick).
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