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Daniel E. Leb, MD; Bernard Weisskopf, MD; Bob S. Kanovitz, MD

Arch Intern Med. 1971;128(3):441-444.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Successful kidney transplantation in young women results in the resumption of normal ovulatory menstrual cycles, so it is not surprising that pregnancies in renal transplant recipients have been reported.^1-4 Since azathioprine is known to produce fetal death and stunt fetal growth and is a teratogenic agent in animals,^5-8 there is valid concern for the human fetus. So far no abnormalities of infants born to women taking azathioprine have been described.^1-4,9,10

This report documents the occurrence of chromosomal abnormalities in the child of a cadaver kidney transplant recipient.

Materials and Methods

Chromosome analysis was performed on peripheral blood leukocytes cultured in the presence of phytohemagglutinin with the use of a slight modification of the technique described by Moorhead et al.¹¹ The slides were stained with Giemsa stain. Chromosomes in 100 metaphases were studied under light microscopy with an oil immersion objective. Karyotypes were prepared by photographic enlargement . . . [Full Text PDF of this Article]

Author Affiliations
Pittsburgh; Louisville

From the Renal Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh; and the departments of medicine and pediatrics, University of Louisville School of Medicine and Child Evaluation Center, Louisville.

Footnotes
Received for publication Nov 16, 1970; accepted Jan 21, 1971.

Read in part before the 50th annual meeting of the American College of Physicians, April 14, 1970.

Reprint requests to Department of Medicine, Presbyterian-University Hospital, Room 11430, 230 Lothrop St, Pittsburgh 15213 (Dr. Leb).

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