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Goodpasture SyndromeDissociation From Antibodies to Glomerular Basement Membrane
Gregory J. Beirne, MD;
William L. Kopp, MD;
Stephen W. Zimmerman, MD
Arch Intern Med. 1973;132(2):261-263.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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Immunologic studies of patients with Goodpasture syndrome have demonstrated antibodies to glomerular basement membrane in glomeruli and serum.1,2 Using immunofluorescent techniques, investigators have identified linearly deposited immunoglobulin G (IgG) along these membranes.3,4 In addition, serum and eluates of kidneys of these patients cross-react with alveolar basement membranes.5,6 Such observations suggest that antibodies may mediate both pulmonary hemorrhage and glomerulonephritis in patients with Goodpasture syndrome. Studies of kidney disease produced by heterologous antilung antibodies support this hypothesis.7-9 Nevertheless, direct evidence that antibodies to alveolar basement membranes cause pulmonary hemorrhage in Goodpasture syndrome is lacking.
We describe a patient with typical clinical and histologic abnormalities of Goodpasture syndrome, but with granular deposits of IgG and β1C-globulin on kidney basement membranes. Our observations illustrate that antibodies to glomerular basement membrane do not exclusively cause the glomerulitis of Goodpasture syndrome.
Patient Summary
A 16-year-old boy was admitted to
. . . [Full Text PDF of this Article]
Author Affiliations
Madison, Wis
From the Nephrology Program, Veterans Administration Hospital, and the Department of Medicine, University of Wisconsin Medical School, Madison.
Footnotes
Received for publication Feb 18, 1972; accepted Feb 24.
Reprint requests to Veterans Administration Hospital, 2500 Overlook Terrace, Madison, WI 53705 (Dr. Beirne).
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