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Cytogenetic, Endocrine, and Testicular Steroidogenesis Studies

Howard R. Nankin, MD; John B. Talbott, MD; Hiroyuki Oshima, MD; Der-Fong F. Fan, PhD; Sylvia F. Pan, MD; Philip Troen, MD

Arch Intern Med. 1974;134(2):352-358.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1959, Down syndrome was shown to be associated with an extra chromosome in the G group¹; Klinefelter syndrome was associated with an extra X chromosome²; and a case of double aneuploidy, a 48,XXY,G + male, was reported.³ In 1971, Erdtmann et al summarized 16 cases with this form of double aneuploidy.⁴ Two of the patients were adults, and these men had obvious phenotypic abnormalities. We report here results of endocrine, cytogenetic, and in vitro testicular steroidogenesis studies in a 19-year-old man with a 48,XXY,G + chromosome constitution, who lacked many of the classical features of Down or Klinefelter syndromes.

Patient Summary

A white man aged 19 years 3 months was referred because of underdeveloped testes, incomplete sexual maturation, and obesity. He had the following history: The second of four children, he was born following an uncomplicated pregnancy and delivery. As he grew, obesity and a moderate degree . . . [Full Text PDF of this Article]

Author Affiliations
Pittsburgh

From the Department of Medicine, Montefiore Hospital (Drs. Nankin, Talbott, Oshima, Fan, and Troen), and the Department of Radiation Medicine, Presbyterian-University Hospital, University of Pittsburgh School of Medicine (Dr. Pan). Dr. Talbott was a medical student with an elective in reproductive endocrinology, Montefiore Hospital.

Footnotes
Submitted for publication April 2, 1973; accepted April 19.

Reprint requests to 3459 Fifth Ave, Pittsburgh, PA 15213 (Dr. Nankin).

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