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Synergistic Effect of Prednisone on Long-Term Treatment of Hypercalcemia

William Y. W. Au, MD

Arch Intern Med. 1975;135(12):1594-1597.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The inadequacy of long-term treatment for control of hypercalcemia is exemplified by the difficulties encountered in patients with recurrent parathyroid carcinoma. Among the approaches currently used, phosphate^1,2 and mithramycin,³ although effective, may be associated with toxic effects, while calcitonin, which theoretically should be ideal for this problem because of its specific ability to inhibit parathyroid hormone-stimulated bone resorption and its lack of toxic effects, has been disappointing clinically because the initial effects are often not sustained.⁴ "Escape" from the inhibitory effects of calcitonin has been observed in organ culture⁵ as well as in vivo⁶ and may be due to changes in cellular responses to calcitonin rather than to the development of secondary increase in parathyroid hormone output,⁷ or to development of antibodies to calcitonin.⁸ Recent studies in organ culture showed that the escape of parathyroid hormone-stimulated resorption from calcitonin inhibition can be prevented by simultaneous treatment with glucocorticoids.⁹ This report . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Medicine, Rochester General Hospital and the departments of pharmacology and toxicology and medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY.

Footnotes
Received for publication Jan 23,1975; accepted March 22.

Reprint requests to 601 Elmwood Ave, Rochester, NY 14642 (Dr. Au).

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