This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (5)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Richard M. Timms, MD; Kenneth M. Moser, MD

Arch Intern Med. 1975;135(12):1601-1603.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The association of pulmonary disease and chloroform (CHCL₃) injection has not been recorded previously in humans as far as we know. However, other halogenated, volatile hydrocarbons such as carbon tetrachloride and trichlorethane are known to induce pulmonary injury. Carbon tetrachloride (CHCL₄) causes pulmonary edema and hemorrhage when given intravenously to dogs.¹ Oral doses of carbon tetrachloride were recently shown to cause diffuse pulmonary damage in rats at sublethal dosage levels.² There is evidence that inhaling high concentrations of trichloroethane (CH₃CCL₃) may cause pulmonary disease.^3,4

In 1973, the Federal Food and Drug Administration concluded that trichloroethane may be responsible for side-effects from over-the-counter aerosols, and they asked that manufacturers of aerosols containing trichloroethane recall their products.⁵ Most patients who have ingested toxic doses of chloroform or trichloroethane have apparently not developed secondary pulmonary disease. The clinical course of a patient who developed pulmonary infiltrates and acute respiratory distress after injecting chloroform . . . [Full Text PDF of this Article]

Author Affiliations
From the Pulmonary Division, Department of Medicine, University of California, San Diego.

Footnotes
Received for publication Dec 30,1974; accepted Feb 26, 1975.

Reprint requests to 225 W Dickinson St, San Diego, CA 92103 (Dr. Timms).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?