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Documented Cure With Combined Chemotherapy

John A. Ostuni, MD; Martin S. Roginsky, MD

Arch Intern Med. 1975;135(9):1257-1258.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

We believe that a patient with adrenal carcinoma and widespread metastasis¹ was cured of metastatic adrenal carcinoma by chemotherapy, and we wish to report this cure.

PATIENT SUMMARY

The patient was a 17-year-old woman when she first came to Nassau County Medical Center in December 1964 with abdominal pain. In May of that year, a diagnosis of Cushing syndrome was made and confirmed by the finding of elevated urinary steroid levels at another hospital. In June, an adrenal carcinoma weighing 1,520 gm was surgically removed from the left side. Immediately following surgery, the patient did well with resolution of the Cushing syndrome; however, by December, mild weight gain and hirsutism had reoccurred. Twenty-four-hour urinary 17-ketogenic and 17-ketosteroid steroid levels were elevated, 45 mg and 22 mg, respectively, and were not suppressible by dexamethasone, 2 mg/day for two days. The plasma cortisol level was also elevated (26.5µg/100 ml) and without . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Medicine, Division of Endocrinology, Nassau County Medical Center, East Meadow, NY, and the State University of New York at Stony Brook.

Footnotes
Received for publication Dec 11, 1974; accepted Jan 3, 1975.

Reprint requests to 2201 Hempstead Turnpike, East Meadow, NY 11554 (Dr. Roginsky).

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