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Report of Familial Occurrence and Discussion of the Implications of Transfusion Therapy

S. Gerald Sandler, MD; Avinoam Zlotnick, MD

Arch Intern Med. 1976;136(1):93-94.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Selective IgA deficiency is a common immunodeficient state that occurs in healthy individuals with a frequency ranging from 1:700¹ to 1:3,040², depending on population selection and diagnostic criteria. Selective IgA deficiency is associated also with a variety of clinical disorders, including chronic respiratory,^3-5 gastrointestinal,^6-8 and autoimmune diseases.^9-11 Familial studies of IgA-deficient persons often detect relatives with other immunoglobulin deficiencies.¹² Occasionally, selective IgA deficiency occurs in families as an autosomal-recessive trait,^13-15 a dominant trait,^16,17 or a dominant trait with intermediate inheritance.⁵ We report a mother with autoimmune hemolytic disease (AHD) of 20 years' duration and selective IgA deficiency, whose only child also has selective IgA deficiency. To our knowledge, this is the first report of familial selective IgA deficiency associated with AHD.

PATIENT SUMMARY

A 56-year-old Ashkenazi woman was admitted to the Hadassah-Hebrew University Medical Center for management of chronic hemolytic anemia. . . . [Full Text PDF of this Article]

Author Affiliations
From the Blood Bank and the Department of Medicine A, Hadassah University Hospital and Medical School, Jerusalem, Israel.

Footnotes
Received for publication April 11, 1975; accepted June 27.

Reprint requests to Blood Bank, Hadassah University Hospital, Jerusalem, Israel (Dr Sandler).

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