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Candida Endocarditis in Two Patients
Nalini Premsingh, MD;
Rajendra Kapila, MD;
Flor Tecson, MD;
Leon G. Smith, MD;
Donald B. Louria, MD
Arch Intern Med. 1976;136(2):208-212.
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Candida endocarditis was first described in 1939 by Freedman and Donaldson as an unidentified yeast on the aortic valve. Since then, numerous reports have been published. No effective treatment was available before the introduction of amphotericin B, although Harrell and Thompson did report successful treatment with nystatin in one case.1 The following cases prompted us to review the literature regarding the management of this disease.
PATIENT SUMMARIES
PATIENT 1.—
A 17-year-old male heroin user entered the Martland Hospital in May 1973, with a two-week history of increasing shortness of breath, anorexia, and vomiting. Fever with chills supervened five days prior to admission. He had experienced rheumatic fever at the age of seven years, and seven years later he was found to have mitral stenosis and incompetence. Three years before admission, the mitral valve was replaced by a Starr-Edwards prosthesis. Thereafter, the patient was unavailable for follow-up and did not
. . . [Full Text PDF of this Article]
Author Affiliations
From the Department of Medicine, Englewood (NJ) Hospital (Dr Premsingh), the departments of preventive medicine and community health, and medicine, New Jersey Medical School, Newark (Drs Kapila, Tecson, and Louria), and the Department of Medicine, St. Michael's Medical Center, Newark (Dr Smith).
Footnotes
Received for publication Sept 11, 1974; accepted April 14, 1975.
Reprint requests to Room 1216, 100 Bergen St, Newark, NJ 07103 (Dr Louria).
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