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Idiopathic Late-Onset Immunoglobulin Deficiency With Functional T-Cell Deficiency
Walter R. Wilson, MD;
Paul E. Hermans, MD;
Roy E. Ritts, Jr, MD
Arch Intern Med. 1976;136(3):343-346.
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When combined deficiency of both thymus - derived lymphocytes (T-cells) and bone-marrow-derived lymphocytes (B-cells) occurs as a congenital disorder, it is characterized by the onset in early life of severe viral, fungal, and bacterial infections and by early death, most often within the first two years of life.1 In congenital combined deficiency, there is a quantitative deficiency of both T-cells and B-cells. Combined T-cell and B-cell dysfunction may occur also in association with lymphoproliferative disorders. Observations on combined idiopathic late-onset immunoglobulin deficiency and severe qualitative T-cell dysfunction are rare.2 This paper describes the clinical courses and immunologic data in two patients with idiopathic late-onset combined immune deficiency.
PATIENT SUMMARIES
PATIENT 1.—
A 51-year-old woman was first seen in January 1959. She reported having had fatigue, morning stiffness, and arthralgia of both hands, wrists, and elbows, recurrent respiratory infections, and splenomegaly for 12 years. The respiratory infections caused her to
. . . [Full Text PDF of this Article]
Author Affiliations
From the Division of Infectious Diseases, Department of Internal Medicine, and the Department of Microbiology, Mayo Clinic and Mayo Foundation, Rochester, Minn.
Footnotes
Received for publication May 2, 1975; accepted Aug 13.
Reprint requests to Section of Publications, Mayo Clinic, Rochester, MN 55901 (Dr Wilson).
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