• Online Features  This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (14)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

William J. Snape, Jr, MD; Sidney Cohen, MD

Arch Intern Med. 1976;136(5):538-542.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

During the past decade, no concept in esophageal physiology or pathophysiology has generated more interest than the proposal that esophageal function may be regulated by the gastrointestinal hormones. Prior to the finding that hormonal substances released in the gastrointestinal tract altered esophageal muscular function, one generally conceived of the esophagus and its sphincters as static systems that responded only to mechanical forces and neural stimuli. The control of esophageal function by peptide hormones released during the normal digestive processes suggested that many unexplained esophageal symptoms may now be clarified by demonstrating pathophysiologic mechanisms of hormonal action. Furthermore, the treatment of these disorders seemed possible through changing these hormonal effects.

The purpose of this review is twofold: first, to describe in detail the effect of each gastrointestinal hormone on esophageal function in man; and second, to evaluate the possible role of this hormonal action in specific esophageal disorders. Most of this . . . [Full Text PDF of this Article]

Author Affiliations

Footnotes

Reprint requests to the Department of Medicine, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 (Dr Cohen).

CiteULike    Connotea    Delicious    Digg    Facebook    Reddit    Technorati    Twitter     What's this?