This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (7)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Judith A. Wolfe, MD; Richard Plotzker, MD; Frank J. Safina, MD; Maria Ross, MD; George Popky, MD; Walter Rubin, MD

Arch Intern Med. 1976;136(8):923-925.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Ulceration, inflammation, and hemorrhage of the upper gastrointestinal tract have been associated with the use of anti-inflammatory drugs, especially aspirin.¹ Mefenamic acid is a relatively new antiinflammatory analgesic agent² that has been thought to be remarkably safe from such gastrointestinal complications,^3-9 although it has many of the physicochemical and pharmacologic properties of aspirin,^2.10 and has been known to produce gastrointestinal ulceration in rats and monkeys when administered in very large doses.^11.12 We describe a patient who developed an unusual bleeding ulcer in the third portion of the duodenum, duodenitis, and antral gastritis while receiving mefenamic acid.

PATIENT SUMMARY

A 46-year-old black woman was admitted to the Hospital of the Medical College of Pennsylvania on Oct 22, 1974, with melena and hematemesis. The patient had suffered from osteoarthritis of the spine for one year. Two weeks prior to admission, her physician prescribed mefenamic acid (Ponstel Kapseals), . . . [Full Text PDF of this Article]

Author Affiliations
From the Division of Gastroenterology, Department of Medicine (Drs Wolfe, Plotzker, Safina, and Rubin), and the Department of Radiology (Drs Ross and Popky), Medical College of Pennsylvania, Philadelphia.

Footnotes
Received for publication Oct 29, 1975; accepted Dec 15, 1975.

Reprint requests to the Department of Medicine, Medical College of Pennsylvania, 3300 Henry Ave, Philadelphia, PA 19129 (Dr Rubin).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?