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New Concepts

Sidney Cohen, MD; William J. Snape, Jr, MD

Arch Intern Med. 1978;138(9):1398-1401.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Gastroesophageal reflux disease refers to a clinical syndrome produced by the passage of gastric contents into the esophagus. The syndrome is usually manifested by the symptoms of heartburn, and may lead to the sequelae of esophagitis, stricture, or peptic ulcer of the esophagus. The frequency of the syndrome is unknown since most persons report symptoms of heartburn at some time. The sequelae or complications of gastroesophageal reflux are less common, but yet present a major problem for the practicing physician. Recent developments in the pathophysiology of gastroesophageal reflux now provide a better understanding for the diagnosis and treatment of this disorder.

The purpose of this review is to discuss (1) recent developments in the pathophysiological mechanism of gastroesophageal reflux; (2) a rational clinical approach to the documentation of gastroesophageal reflux and its complications; and (3) the recent advances in the medical and surgical therapy of this disorder.

PATHOPHYSIOLOGY OF GASTROESOPHAGEAL . . . [Full Text PDF of this Article]

Author Affiliations
From the Gastrointestinal Section, Department of Medicine, University of Pennsylvania at the Hospital of the University of Pennsylvania, Philadelphia.

Footnotes
Accepted for publication Nov 14, 1977.

Reprint requests to Gastrointestinal Section, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 (Dr Cohen).

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