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Hector F. DeLuca, PhD

Arch Intern Med. 1978;138(Suppl 5):836-847.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

From intensive work carried out during the past decade, it is clear that vitamin D must be metabolized before it can function.¹ One of the central metabolites in this phenomenon is 25-hydroxyvitamin D₃ (25OHD₃), to which this publication is devoted. It is also known that 25OHD₃ is metabolized further to an active hormone, 1,25-dihydroxyvitamin D₃ (1,25[OH]₂D₃). This report will review the physiology and biochemistry underlying the use of calcifediol (25OHD₃) in the treatment of disease even in circumstances where there is a lack of 1,25(OH)₂D₃.

FUNCTIONS OF VITAMIN D

Vitamin D is unique among the vitamins in the sense that it is a precursor of at least one hormone and, hence, vitamin D₃ must be regarded as a prohormone^1-5 (Fig 1). The numbering system in the molecule is confusing because it is derived from cholesterol, which is . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Madison.

Footnotes
Read before the Upjohn Co, Kalamazoo, Mich, Nov 1, 1976.

Reprint requests to Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Madison, WI 53706 (Dr DeLuca).

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