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Raymond V. Randall, MD

Arch Intern Med. 1979;139(10):1092.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

After the initial report by Linfoot and co-workers in 1970,¹ it has been assumed that an abnormal increase in the concentration of an anterior pituitary hormone in the CSF is indicative of suprasellar extension of the pituitary tumor producing that hormone. The report by Jordan et al in the February issue of the ARCHIVES (139:208-211, 1979) and a recent corroborative report by Assies and associates² show that prolactin is an exception to this assumption, and that substantial elevations of prolactin levels in the CSF can be found in association with a prolactin-producing tumor that has no demonstrable suprasellar extension. This was also noted in one of the patients described by Schroeder et al.³ Furthermore, all three groups of authors showed that CSF prolactin level is increased at term in pregnant women who are not known to have pituitary abnormalities. Assies et al also found that patients with . . . [Full Text PDF of this Article]

Author Affiliations
Mayo Clinic Rochester, MN 55901

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