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Lee Frank, MD, PhD; Donald Massaro, MD

Arch Intern Med. 1979;139(3):347-350.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Within just a short time after the discovery of oxygen 200 years ago, Joseph Priestley, one of its codiscoverers, was already cautioning that oxygen "might burn the candle of life too quickly, and too soon exhaust the animal powers within."¹ Priestley's prescient speculations about the toxic nature of excess O₂. have been confirmed by a host of succeeding investigators.

Today, most clinicians are well aware of the toxic consequences to the lung of prolonged exposure to high tensions of O₂, yet physicians involved in intensive care are frequently confronted by situations in which prolonged hyperoxic therapy is a necessary part of the management of neonatal and adult patients with severe respiratory distress. Unfortunately, no pharmacological agent is available to help circumvent the development of pulmonary toxicity associated with prolonged high oxygen therapy. The spectrum of O₂-induced lung injury, including pulmonary edema, atelectasis, consolidation, congestion, hemorrhage, . . . [Full Text PDF of this Article]

Author Affiliations
From the Pulmonary Division, the Calvin and Flavia Oak Asthma Research and Treatment Center, University of Miami School of Medicine, and the Veterans Administration Hospital, Miami.

Footnotes
Accepted for publication Oct 18, 1978.

Reprint requests to Pulmonary Division R120, Department of Medicine, University of Miami School of Medicine, PO Box 016960, Miami, FL 33101 (Dr Frank).

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