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Robert M. Carey, MD

Arch Intern Med. 1981;141(12):1594.

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Hypertension and hypokalemia related to excessive aldosterone secretion by an adrenal adenoma was first described by Jerome Conn in 1955.¹ Since that time, four subgroups of patients with primary aldosteronism have been characterized, including those with aldosteroneproducing adenoma (APA), idiopathic hyperaldosteronism (IHA), glucocorticoid remediable hyperaldosteronism, and indeterminant hyperaldosteronism.^2-4 Of these causes of primary aldosteronism, APA accounts for approximately 60% and IHA for about 40%, and the other two disorders are rare. Only patients with APA predictably respond to a specific surgical approach with normalization of blood pressure,⁵ so that identification of primary aldosteronism and differentiation from the other forms of the disease have important clinical relevance. Nevertheless, a convenient, economical, and reliable diagnostic screening test for surgically correctable primary aldosteronism heretofore has not been available; and patients suspected as having surgically remediable hypertension caused by primary aldosteronism have had to be admitted to the hospital for a . . . [Full Text PDF of this Article]

Author Affiliations
Department of Internal Medicine University of Virginia School of Medicine Charlottesville, VA 22901

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