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James M. Hughes, MD; Carol O. Tacket, MD

Arch Intern Med. 1983;143(3):425-427.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The article by Schmidt-Nowara et al (p 451) provides data on early and late pulmonary manifestations and complications of botulism, a rare disease which was recognized as a clinical entity in the late 18th and early 19th centuries in Germany where it was referred to as "sausage poisoning." In a classic investigation in Belgium in 1895, van Ermengem¹ discovered that the disease was an intoxication and first isolated the responsible organism, Clostridium botulinum.² The first botulism outbreak reported in the United States occurred in 1899.³

See also p 451.

The pathogenesis of botulism may involve either ingestion of preformed botulin toxin or toxin production by C botulinum in vivo (toxicoinfection). Foodborne botulism, the syndrome recognized in Germany almost 200 years ago, results from ingestion of preformed toxin. Wound botulism (first recognized in 1943⁴) and infant botulism (first described in 1976⁵ although cases occurring in 1931 . . . [Full Text PDF of this Article]

Author Affiliations
Center for Infectious Diseases Centers for Disease Control Department of Health and Human Services Public Health Service Atlanta, GA 30333

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