This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (5)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Robert E. Wolf, MD, PhD

Arch Intern Med. 1984;144(8):1658-1660.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Over the past decade, many new nonsalicylate, nonsteroidal anti-inflammatory drugs (NSAIDs) have been introduced in the United States. These include fenoprofen, ibuprofen, meclofenamate, naproxen, piroxicam, sulindac, and tolmetin in addition to indomethacin and phenylbutazone, which were previously available. These drugs have added to our therapeutic armamentarium for management of degenerative joint disease (DJD) and rheumatoid arthritis (RA) as well as other rheumatic and nonrheumatic disorders.

CLASSIFICATION AND CLINICAL PHARMACOLOGY

Figure 1 provides a chemical classification of currently available NSAIDs. Although these groupings do not hold notable clinical relevance, differences among the classes may be unveiled as we gain more understanding of their pharmacologic activity.

All NSAIDs are rapidly absorbed and highly protein bound with peak serum levels occurring within four hours after ingestion. Half-life varies from two to 50 hours with excretion via urine, bile, and feces as inactive metabolites, with less than 10% excreted unchanged. At pharmacologic doses, NSAIDs . . . [Full Text PDF of this Article]

Author Affiliations
From the Section of Rheumatology, the Department of Medicine, Louisiana State University Medical Center, Shreveport.

Footnotes
Accepted for publication Jan 22,1984.

Reprint requests to Section of Rheumatology, Department of Medicine, PO Box 33932, Louisiana State University Medical Center, Shreveport, LA 71130 (Dr Wolf).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?