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R. Wayne Rundles, MD

Arch Intern Med. 1985;145(8):1492-1503.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The Clinical Research Unit (CRU) program of the National Institutes of Health, developed in the late 1950s, proved to be an important innovation in the use of public funds to support medical research. The establishment of these units led to a material improvement in the quality, convenience, and feasibility of many types of investigation involving human subjects. Their contribution in one area is illustrated by studies that led to the development of allopurinol as an agent to control the production of uric acid in gout and hyperuricemia in man. The route by which this drug was developed was serendipitous, and ultimate success depended on the fortuitous collaboration of individuals with biochemical, pharmacologic, and medical research interests working with substantial institutional support.

Historically, the importance of medical research in public health and national defense matters gained recognition slowly for nearly a century before it attracted major support from either private or . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Medicine, Duke University School of Medicine, Durham, NC.

Footnotes
Accepted for publication Oct 25, 1984.

Reprint requests to Department of Medicine, Duke University School of Medicine, Durham, NC 27710 (Dr Rundles).

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