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Charles van Heyningen, MRCPath
Kingston-upon-Thames, England

Arch Intern Med. 1986;146(1):203-207.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—Hypertriglyceridemia, a common finding in diabetes mellitus, has been shown to falsely elevate glycosylated hemoglobin (GHbA₁) levels when measured by cation-exchange column chromatography.^1,2 Falko et al¹ demonstrated this effect in vivo when triglyceride concentrations exceed 1,750 mg/dL (20 mmole/L) and confirmed this by the in vitro addition of lipemic plasma to a control sample. A triglyceride concentration of 9,316 mg/dL (105 mmole/L) produced an apparent eightfold increase in GHbA₁.

Estimation of GHbA₁ levels by affinity chromatography as described by Hall et al³ is becoming increasingly used and it is, therefore, important to know whether the same effect is found.

We have used this method to investigate the effects of lipemia on GHbA₁ estimations. Glycosylated hemoglobin levels were estimated on grossly lipemic samples (with plasma triglyceride concentrations of 43, 48, and 89 mmole/L, respectively) from three patients, using both washed and . . . [Full Text PDF of this Article]

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