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Donald O. Castell, MD

Arch Intern Med. 1987;147(10):1701-1702.

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Gastroesophageal (GE) reflux and its many sequelae represent common and often relentless problems in management of patients. It has been estimated that approximately 10% of the population in the United States will have heartburn on a daily basis.¹ Many recent clinical trials have indicated that there are a variety of effective short-term therapies for the relief of reflux symptoms, including H₂ receptor blockers, metoclopramide, and bethanechol.^2-5 There is, however, little information available on effective long-term maintenance therapies of this common, persistent problem. In this issue of the ARCHIVES, Dr Lieberman⁶ provides us with some interesting information in a group of 20 patients with chronic GE reflux disease followed up for up to 42 months. In all of these patients, their symptoms had initially been so persistent that even a standard dose of cimetidine (300 mg four times daily) had failed to improve their symptoms until this . . . [Full Text PDF of this Article]

Author Affiliations
Gastroenterology Section Bowman Gray School of Medicine of Wake Forest University 300 S Hawthorne Rd Winston-Salem, NC 27103

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