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MARC FISHER, MD; PETER H. LEVINE, MD; ALEXANDER LEAF, MD

Arch Intern Med. 1989;149(8):1726-1728.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

M ounting interest has been generated over the past decade concerning the potential beneficial effects of n-3 fatty acids on atherosclerosis and atherothrombotic disorders. Substantial quantities of epidemiological and laboratory data have accumulated regarding n-3 fatty acids and atherosclerosis.^1,2 The purpose of this review is to summarize recent studies that have sought to elucidate the biochemical and cellular effects by which n-3 fatty acids might favorably affect atherogenesis. We will begin with a very brief review of the clinical and epidemiological data.

EPIDEMIOLOGICAL, CLINICAL, AND EXPERIMENTAL OBSERVATIONS

Epidemiological studies of Greenland and Alaskan Eskimos have demonstrated a substantially reduced mortality rate of ischemic heart disease in these populations compared with European and North American cohorts.^3,4 Analysis of the Eskimo diet revealed differences from typical Western diets, especially in the fatty acid content, which contained substantial quantities of n-3 fatty acids derived from marine sources.⁵ Similar studies in . . . [Full Text PDF of this Article]

Author Affiliations
Departments of Medicine and Neurology; Department of Medicine The Medical Center of Central Massachusetts-Memorial University of Massachusetts Medical School 119 Belmont St Worcester, MA 01605; Department of Preventive Medicine Harvard Medical School Boston, MA 02115

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