This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

H. VIERHAPPER, MD
Vienna, Austria

Arch Intern Med. 1990;150(11):2420.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor. — In a recent communication, Allen et al¹ report that indomethacin, a compound used for some time² to reduce diuresis in nephrogenic diabetes insipidus, may also be effective in patients in whom this condition has been induced by lithium therapy. Since in the interpretation of their results, indomethacin is used virtually synonymously with "NSAID" the authors should be reminded that both in healthy subjects and in a patient with nephrogenic diabetes insipidus, the comparison of the potential antidiuretic effect of indomethacin vs that of acetylsalicylic acid, another inhibitor of cyclo-oxygenase activity, has indicated that a mechanism other than cyclo-oxygenase inhibition is involved in the effect of indomethacin.^3,4 To relate the antidiuretic action of indomethacin in nephrogenic diabetes insipidus only to its effect on cyclo-oxygenase is therefore an oversimplification. . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?