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Is It Really Thyroid Disease?

STEVEN E. FELDON, MD

Arch Intern Med. 1990;150(5):948-950.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The triad of hyperthyroidism, diffuse goiter, and ophthalmopathy was identified as a disease entity by Parry, ¹ Graves, ² and von Basedow³ in the first part of the 19th century. Although there is a strong temporal relationship between the onset of hyperthyroidism and eye symptoms, ⁴ many patients with hyperthyroidism do not experience clinical eye findings, and some patients with ophthalmopathy fail to manifest overt or subclinical signs of thyroid dysfunction.^5-9 The absence of a consistent linkage between the thyroid disease and the eye disease has been an impediment to the identification of a common causal agent and to agreement on the optimal clinical management of the ophthalmopathy.

See also p 1098.

Graves' disease is considered to be autoimmune in origin. Thyroid-stimulating immunoglobulins stimulate the thyroid-stimulating—hormone receptor on the thyroid cell membrane.¹⁰ Some thyroid-stimulating immunoglobulins were once thought to cause ophthalmopathy, but that belief is no longer . . . [Full Text PDF of this Article]

Author Affiliations
Department of Ophthalmology University of Southern California 1355 San Pablo St Los Angeles, CA 90033

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