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E. Nigel Harris, MPhil, MD, DM; Kathleen Bos, MD

Arch Intern Med. 1991;151(2):231-233.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The occurrence of venous and arterial thrombosis, recurrent pregnancy losses, and thrombocytopenia in patients with antiphospholipid (aPL) antibodies has been well documented.^1,2 Antiphospholipid antibodies are autoantibodies that bind a variety of negatively charged phospholipids, the best known of which is cardiolipin.^1,2 Some authors^3-6 suggest that patients with these antibodies may represent a separate disease entity termed the antiphospholipid syndrome (APS). In addition to thrombosis, recurrent pregnancy losses, and thrombocytopenia, reported clinical features include livedo reticularis and possibly other skin lesions,⁶ heart valve abnormalities,^7,8 and a variety of neurologic disorders.⁹ Laboratory features include a persistently elevated anti-cardiolipin test, usually IgG isotype,^3,10 and/or an unequivocally positive lupus anticoagulant test.^2,14 About half of the patients with the APS seen by rheumatologists have systemic lupus erythematosus (SLE), but in nonrheumatologic practices, the percentage of patients with SLE is much lower.

Clinical features that should prompt an . . . [Full Text PDF of this Article]

Author Affiliations
Division of Rheumatology Department of Medicine 530 S Jackson St Louisville, KY 49292

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