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The Jury Is Still Out

Farley R. Cleghorn, MD, MPH; William A. Blattner, MD

Arch Intern Med. 1992;152(7):1372-1373.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In this issue of the ARCHIVES, Gotuzzo et al¹ provide evidence that human immunodeficiency virus type 1 (HIV-1) and human T-cell lymphotropic virus type I (HTLV-I) coinfection is associated with a more severe clinical course with shortened survival for acquired immunodeficiency syndrome (AIDS). The teleological attraction of epidemiologic findings such as this, as with prior population studies of coinfected persons,^2-4 is that in vitro molecular and biochemical studies suggest that other viruses can enhance the replication and expression of HIV-1. Viruses for which this effect has been demonstrated include HTLV-I,⁵ HTLV type II (HTLV-II),⁶ cytomegalovirus,⁷ human herpes virus type 6,⁸ herpes simplex virus,⁹ and Epstein-Barr virus.¹⁰ For example, the envelope peptides of both HTLV-I and HTLV-II have been reported to activate T cells, resulting in enhanced HIV-1 expression.⁶ In addition, the tax gene product of HTLV-I (the regulatory element of HTLV-I . . . [Full Text PDF of this Article]

Author Affiliations
National Cancer Institute Division of Cancer Etiology Viral Epidemiology Section 6130 Executive Blvd EPN/434 Rockville, MD 20852

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