This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (11)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Umberto Tirelli, MD; Antonio Pinto, MD; Giuseppe Marotta, MD
Aviano, Italy

Marina Crovato, PhD
Pordenone, Italy

Michele Quaia, PhD
Aviano, Italy

Paolo De Paoli, MD
Pordenone, Italy

Enzo Galligioni, MD
Aviano, Italy

Gianfranco Santini, MD
Pordenone, Italy

Arch Intern Med. 1993;153(1):116-120.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Chronic fatigue syndrome (CFS) is a recently defined illness of unknown cause, characterized by unexplained disabling fatigue and neuropsychological symptoms such as difficulties with concentration and depression.¹ Recently, DeFreitas et al² have evidenced by polymerase chain reaction and in situ hybridization assays that the majority of 34 patients with CFS and some of their household and casual contacts appeared to be infected with a retrovirus related, but not identical, to human T-lymphotropic virus type 2 (HTLV-2). Other viruses such as human herpes virus 6 (HHV-6)³ or enterovirus⁴ have been implicated in the cause of CFS. Conflicting results on the immunologic abnormalities of CFS have been reported in the literature,^5,6 although a recent report suggests T-cell activation and natural killer (NK) cell activity depression as the main immunologic features of CFS.⁷ Chronic fatigue syndrome has been described mainly in the United States, Australia, and Great . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?