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Ernest H. Friedman, MD
East Cleveland, Ohio

Arch Intern Med. 1993;153(10):1268-1271.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The inverse association of serum cholesterol levels and noncardiovascular causes of death¹ may have been due to an increased risk in subjects lowering their cholesterol concentration by diet or drugs.² This hypothesis is supported by diurnal variation of serotonin and suicide^3-5 and by decreased serotonergic-mediated inhibition of dopamine^6,7 subserving alcohol-seeking behavior⁸ and mood.^9,10 The fact that delay-dependent speeding of reaction time, reflecting motor readiness, is abolished by depletion of dopamine suggests monitoring behavioral correlates of mood, ie, speech hesitation and switching pauses,^11,12 to clarify the etiologic relationships of these inverse associations.¹ . . . [Full Text PDF of this Article]

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