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Harvey E. Golden, MD
Chicago, Ill

Arch Intern Med. 1993;153(11):1396.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Regarding the article "Herpes Simplex Virus Associated With Recurrent Stevens-Johnson Syndrome" (SJS) by Detjen et al,¹ I would like to provide some information about my own experience in preventing herpes simplex-associated SJS and to raise a question.

In the period 1962 through 1966, I had recurrent episodes of SJS of progressive severity, requiring hospitalization on two occasions, each preceded by an episode of herpes simplex labialis that had begun 7 to 10 days before. Because this was before the availability of acyclovir, I began to treat myself with high doses of prednisone about 5 days after my original lip lesion developed, ie, at a time when there was no longer a vesicle, but the beginning of healing.

This strategy prevented recurrent episodes of severe stomatitis and SJS, and if I reduced the dose of prophylactic prednisone too far (from 40 to 20 mg/d for 7 days) I might get . . . [Full Text PDF of this Article]

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