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Richard K. Severson, PhD; Martha S. Linet, MD

Arch Intern Med. 1993;153(4):425-427.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The LEUKEMIAS constitute less than 5% of malignancies in most countries, but they have received extensive epidemiologic attention because of the high case-fatality rate and the heterogeneity of a growing number of recognized subtypes.^1,2 Leukemia was the first neoplasm to occur in excess among the Japanese atomic bomb survivors, to develop with increased incidence among patients treated with alkylating agents, and to be conclusively linked with a human retrovirus. Because these and other recognized etiologic factors account for only a small fraction of all leukemia cases, more recent epidemiologic investigations have attempted to quantify leukemia risks that may be associated with cigarette smoking and other more common exposures, including diagnostic roentgenograms, non-ionizing electromagnetic field exposures, solvents, and other chemicals. In this issue of the ARCHIVES, Brownson and colleagues³ present a meta-analysis of epidemiologic studies examining the cigarette smoking—leukemia relationship.

Austin and Cole⁴ were the first to suggest, . . . [Full Text PDF of this Article]

Author Affiliations
Divisions of Epidemiology and Pediatric Oncology University of Minnesota Box 422 UMHC Minneapolis, MN 55455; Epidemiology and Biostatistics Program National Cancer Institute 6230 Executive Blvd Bethesda, MD 20892

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