This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Lessons We Have Learned From Laboratory and Clinical Research

James L. Frey, MD

Arch Intern Med. 1995;155(10):1005-1006.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A VARIETY of treatments have been tested in human trials for acute stroke.^1,2 Many others have been studied in the laboratory.³ Although this work has yet to produce a proven effective treatment for acute stroke, it has generated important lessons that have brought us closer to solutions that may predict the future.

The most important lesson from the study of acute stroke treatment is that "time is brain."^4,5 Treatments that have been effective in laboratory studies have often failed in human trials because the time to treatment was too great.^6-13 Recognition of the "time limits for reversibility of brain ischemia"^14,15 has led to human trials that now require treatment within 6 hours of symptom onset.¹⁶ The logical consequences of this should be more valid assessment of treatment efficacy and increased likelihood of success. The tissue plasminogen activator, streptokinase, heparinoid, N-methyl-D-aspartate receptor antagonist, free radical scavenger, . . . [Full Text PDF of this Article]

Author Affiliations
Neurovascular Section Barrow Neurological Institute 222 W. Thomas Rd Suite 415 Phoenix, AZ 85013

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?