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Ika I. Peleg, MD
Iowa City, Iowa

C. Mel Wilcox, MD
Atlanta, Ga

Arch Intern Med. 1995;155(2):214-217.

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Evidence on the chemopreventive potential of aspirin and other nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) against colorectal cancer is based on experimental cancer in rodents, interventional studies in patients with familial adenomatous polyposis, and some, but not all, epidemiologic investigations.¹ As NSAID use may result in serious renal and gastrointestinal side effects, particularly in the elderly, recommendations on chemoprevention with NSAIDs and the optimal regimen must await efficacy-to-toxicity and risk-to-benefit analyses in prospective controlled trials. . . . [Full Text PDF of this Article]

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