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Once Is Not Enough

Peter W. F. Wilson, MD

Arch Intern Med. 1995;155(20):2146-2147.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

CHOLESTEROL TESTING has changed remarkably since the middle 1980s. Millions of asymptomatic Americans have been tested¹ and retested. The advent of tabletop chemistry analyzers and portable testing devices,² the introduction of medications that favorably affect atherosclerotic risk and prognosis,^3-5 and the dissemination of a National Cholesterol Education Program^6,7 have led to an increase in cholesterol awareness and intervention. An article in this issue of the ARCHIVES⁸ concerns an important facet of this issue: the accuracy and utility of cholesterol testing and retesting.

In this issue of the ARCHIVES, Forrow et al⁸ present data on more than 1000 individuals who participated in a cholesterol screening program and then were retested 17 months later. Participants with initially high levels of cholesterol typically had lower levels at follow-up, and the authors attributed a considerable degree of the reduction to "regression to the mean." These results provide an . . . [Full Text PDF of this Article]

Author Affiliations
Director of Laboratories Framingham Heart Study National Heart, Lung, and Blood Institute 5 Thurber St Framingham, MA 01701

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