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From Pathophysiology to Prevention

Norman M. Kaplan, MD

Arch Intern Med. 1996;156(17):1919-1920.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

MORE THAN HALF of the people in the United States will develop hypertension during their lifetimes, and, as recently reconfirmed,¹ hypertension is the most potent force for the development of the multiple atherosclerotic diseases that are the leading causes of morbidity and mortality in our population. Two of the articles in this issue of the ARCHIVES provide additional evidence for the common association between hypertension and atherosclerosis, one documenting the frequency² and the other describing some additional mechanisms beyond those usually considered.³

Most of the predominately systolic hypertension that appears after 60 years of age can be directly attributed to atherosclerotic encroachment of the larger capacitance arteries, causing systolic pressures to rise inordinately when cardiac output enters a rigid, inelastic vascular bed. In the 15% of people with both high systolic and diastolic pressures that appear earlier in life—the disease called essential hypertension—atherosclerosis is accelerated and . . . [Full Text PDF of this Article]

Author Affiliations
University of Texas Southwestern Medical Center at Dallas 5323 Harry Hines Blvd Dallas, TX 75235-8899

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