This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

C. J. Peters, MD; Ali S. Khan, MD; Sherif R. zaki, MD, PhD

Arch Intern Med. 1996;156(7):705-707.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

HANTAVIRUSES CAUSE chronic infections of rodents and occasionally infect other species as well. Several of the Old World viruses are well known as causes of hemorrhagic fever with renal syndrome (HFRS) in Eurasia. Although HFRS has rarely been described in the United States,¹ it is assumed to be underreported. In 1993, an outbreak of febrile disease resembling adult respiratory distress syndrome occurred in the southwestern United States and was found to be caused by a new hantavirus, Sin Nombre virus.²

The unique pulmonary syndrome (hantavirus pulmonary syndrome [HPS]) differed from the renal disease so prominent in HFRS. Immunohistologic studies provide evidence of compartmentalization of a selective immune response in the lung in combination with large amounts of viral antigens in the pulmonary microvasculature.³ Detailed mechanisms of pathogenesis are not understood, although there are some similarities to HFRS.⁴ Selective inflammatory cell recruitment to the lung may occur . . . [Full Text PDF of this Article]

Author Affiliations
Centers for Disease Control and Prevention Division of Viral and Rickettsial Diseases National Center for Infectious Diseases 1600 Clifton Rd Atlanta, GA 30333

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?