This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Peter W. F. Wilson, MD; William B. Kannel, MD

Arch Intern Med. 1997;157(11):1161-1162.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

KNOWLEDGE ABOUT the role of blood lipids has evolved rapidly since the 1950s when there was preoccupation with neutral fat (triglycerides) and the serum total cholesterol.¹ With the advent of ultracentrifugation, the emphasis shifted to the lipoproteins that transport cholesterol and triglycerides.² Electrophoretic analysis spawned a phenotypic classification system,³ leading to β-and pre-β-lipoproteins becoming the focus of research. Soon it became evident that there was a 2-way traffic of cholesterol entering the arterial intima in the atherogenic low density lipoproteins (LDLs), with removal by other particles, apparently high density lipoproteins (HDLs).⁴ The total-HDL cholesterol ratio was proposed to assess the joint effect of the influences of LDL and HDL. More recently, interest has focused on oxidized LDL, small, dense LDL particles, and triglycerides.⁵

Although not the latest entry, one with an intriguing role in the field of dyslipidemic atherogenesis research is lipoprotein Lp(a). Bearing these . . . [Full Text PDF of this Article]

Author Affiliations
5 Thurber St Framingham, MA 01701

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?