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JOHN A. KILLIAN, Ph.D.; LUDWIG KAST, M.D.

Arch Intern Med. 1921;28(6):813-826.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1897 Schopp and Moraczewski¹ concluded from their studies on urine that the development of carcinomatous growths in the human organism was characterized by a retention of nitrogen. This minus balance was attributed to an increased demand for nitrogen by the malignant tumor. More recent chemical studies on the blood in malignancy, while confirming this observation, have at the same time proffered a different interpretation of the nitrogen retention. The most comprehensive analyses of the blood in malignancy have been placed on record within the last year by Theis and Stone.² Their studies included observations on the nonprotein, urea and amino-acid nitrogen, and the uric acid and sugar in a series of 189 cases, representing a wide range of type and location of malignant neoplasms. They have reported subnormal values for nonprotein and urea nitrogen, particularly in the rapidly growing tumors of the breast and uterus, and an amino-acid nitrogen . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Laboratory of Pathological Chemistry and Department of Medicine, New York Postgraduate Medical School and Hospital, New York City.

Footnotes
Read in part before the American Gastro-enterological Society, Boston, June 7, 1921.

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