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FRED M. SMITH, M.D.

Arch Intern Med. 1921;28(6):836-840.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The nitrites have been employed in the treatment of angina pectoris since the time of Lauder Brunton, and it is well known that in many instances the pain subsides soon after the administration of a pearl of amyl nitrite or a pellet of nitroglycerin. The beneficial action of the nitrites has been considered by some to be due to the fall of blood pressure, and by others it has been held that these drugs dilate the coronary arteries and thus improve the coronary circulation thereby affording relief from the cardiac distress. Experimental observations designed to determine the soundness of the latter view have led to varying conclusions. Meyer¹ and Schloss² observed an increase in the outflow of the coronary vein in the intact heart following the administration of nitrites. Bond,³ on the other hand, failed to get positive results. Voegtlin and Macht⁴ demonstrated a relaxation of coronary arterial rings from . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Internal Medicine Rush Medical College and the Presbyterian Hospital.

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