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R. B. GIBSON, Ph.D.; FRANCIS T. MARTIN, B.S.; MARY VAN RENNSELAER BUELL, Ph.D.

Arch Intern Med. 1922;29(1):82-96.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

We have recently had the opportunity to study the metabolism of nine cases of pseudohypertrophic muscular dystrophy in different stages of advancement. These cases will be reported from a clinical standpoint with about twenty more by Dr. R. V. Funsten. We also include some metabolic observations on other types of atrophic muscular involvement.

Endocrine disturbance in progressive pseudohypertrophic muscular dystrophy is indicated by (1) the hereditary character of the condition, (2) the metabolic abnormalities, (3) the occasional recovery at puberty when glandular readjustments occur, (4) reported improvement following endocrine therapy in some cases, and (5) the development of the disease in polyglandular dystrophies, notably in association with dystrophia adiposogenitalis. Necropsy findings with special reference to the ductless glands are urgently needed to elucidate further the pathogenesis of the condition.

The symptomatology and the pathologic changes have been well reviewed by Timme¹ and by Janney, Goodhart, and Isaacson.²

Involvement of the . . . [Full Text PDF of this Article]

Author Affiliations
IOWA CITY

From the Chemical Research Laboratory of the Department of Theory and Practice of Medicine and Clinical Medicine, in cooperation with the Department of Home Economics and the Graduate College, the State University of Iowa.

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