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WITH SPECIAL REFERENCE TO THE IMMUNITY REACTIONS AND THE COLLOIDAL GOLD TEST ON THE ORIGINAL AND ULTRAFILTERED FLUIDS AND SERUMS

CHARLES E. NIXON, M.D.; KOICHI NAITO, M.D.

Arch Intern Med. 1922;30(2):182-215.

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The investigations reported in this paper have to do with various chemical, physical and immunologic studies of the cerebrospinal fluid and blood of syphilitics and nonsyphilitics and, also, with the factors concerned in the colloidal gold and the Wassermann reactions. The experiments fall more or less into two groups and so, for convenience in discussion, we have divided our paper into two parts: I. Ultrafiltration of Syphilitic Serum; II. The Substances Concerned in the Colloidal Gold Test and the Nature of the Reaction.

Ultrafiltration of Syphilitic Serum

Part I

I. INTRODUCTION

The nature of the active substance concerned in the Wassermann reaction has been discussed by many authors and numerous theories have been advanced as to the nature of this substance. Citron and Reicher¹ regarded it to be of a lipoid nature. Berczeller and Schillinger² extracted syphilitic serum by ether and alcohol. The Wassermann reaction on the serum was weakened . . . [Full Text PDF of this Article]

Author Affiliations
MINNEAPOLIS

Footnotes
From the Division of Nervous and Mental Diseases and the Department of Physiological Chemistry, University of Minnesota, Minneapolis. This work was done under a grant from the United States Interdepartmental Social Hygiene Board. We are indebted to Dr. J. F. McClendon for many valuable suggestions and criticisms and to Dr. S. Marx White for unfailing interest and advice in the course of the work and the preparation of the paper.

Part of the work presented in this paper was submitted as a thesis to the faculty of the Graduate School of the University of Minnesota, in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Nervous and Mental Diseases, 1921. (C. E. N.)

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